2. Round | 12/08/2021 | Real Sociedad | - | Vida | 3:3 | ||||
4. Round | 22/08/2021 | Real España | - | Real Sociedad | 1:1 | ||||
5. Round | 26/08/2021 | Real Sociedad | - | Motagua | 3:3 | ||||
7. Round | 04/09/2021 | Marathón | - | Real Sociedad | 2:1 | ||||
9. Round | 15/09/2021 | Lobos UPNFM | - | Real Sociedad | 2:0 | ||||
10. Round | 19/09/2021 | Platense | - | Real Sociedad | 2:3 | ||||
13. Round | 10/10/2021 | Olimpia | - | Real Sociedad | 4:0 | ||||
15. Round | 24/10/2021 | Motagua | - | Real Sociedad | 5:1 | ||||
18. Round | 10/11/2021 | Real Sociedad | - | Marathón | 0:3 |