6. Round | 14/03/2022 | Club Nacional | - | Libertad | 0:3 | ||||
7. Round | 21/03/2022 | Tacuary | - | Club Nacional | 2:1 | ||||
13. Round | 01/05/2022 | Cerro Porteño | - | Club Nacional | 1:0 | ||||
15. Round | 10/05/2022 | 12 de Octubre de Itauguá | - | Club Nacional | 1:2 | ||||
16. Round | 14/05/2022 | Club Nacional | - | General Caballero DJLM | 1:2 | ||||
17. Round | 23/05/2022 | Libertad | - | Club Nacional | 1:0 | ||||
18. Round | 13/06/2022 | Club Nacional | - | Tacuary | 3:0 | ||||
19. Round | 18/06/2022 | Sportivo Ameliano | - | Club Nacional | 2:2 |