4. Round | 02/02/2021 | Club León | - | Atlético San Luis | 3:1 | ||||
6. Round | 13/02/2021 | Club Tijuana | - | Club León | 2:0 | ||||
7. Round | 21/02/2021 | Pumas UNAM | - | Club León | 0:1 | ||||
8. Round | 28/02/2021 | Club León | - | Cruz Azul | 0:1 | ||||
9. Round | 03/03/2021 | Club León | - | Puebla FC | 1:2 | ||||
11. Round | 16/03/2021 | Club León | - | Club Necaxa | 3:1 | ||||
12. Round | 22/03/2021 | Santos Laguna | - | Club León | 1:2 | ||||
14. Round | 10/04/2021 | Atlas Guadalajara | - | Club León | 1:3 | ||||
15. Round | 20/04/2021 | Club León | - | FC Juárez | 2:0 | ||||
16. Round | 24/04/2021 | Mazatlán FC | - | Club León | 4:3 | ||||
17. Round | 01/05/2021 | Club León | - | Gallos Blancos | 2:1 |