4. Round | 03/02/2022 | Santa Fe | - | Atlético Junior | 2:1 | ||||
5. Round | 08/02/2022 | América de Cali | - | Santa Fe | 2:2 | ||||
6. Round | 13/02/2022 | Santa Fe | - | Deportivo Pereira | 1:2 | ||||
7. Round | 16/02/2022 | Deportes Tolima | - | Santa Fe | 3:0 | ||||
8. Round | 19/02/2022 | Santa Fe | - | Independiente Medellín | 1:0 | ||||
9. Round | 01/03/2022 | Patriotas FC | - | Santa Fe | 1:1 | ||||
10. Round | 06/03/2022 | Santa Fe | - | Millonarios | 0:3 | ||||
12. Round | 22/03/2022 | Santa Fe | - | Atlético Bucaramanga | 3:1 | ||||
14. Round | 04/04/2022 | Santa Fe | - | Unión Magdalena | 1:0 | ||||
17. Round | 25/04/2022 | Millonarios | - | Santa Fe | 2:1 | ||||
20. Round | 15/05/2022 | Once Caldas | - | Santa Fe | 2:2 |