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| 1st(1st leg) | Deportivo Suchitepéquez | - | CSD Municipal | 1:1 (1:0) | ||
| 2nd (2nd leg) | CSD Municipal | - | Deportivo Suchitepéquez | 3:3 (3:1) | ||
| 1st(1st leg): 29/11/2012 00:30 | 2nd (2nd leg): 01/12/2012 21:00 | Winner: Deportivo Suchitepéquez | ||||
| 1st(1st leg) | Deportivo Marquense | - | CSD Comunicaciones | 2:2 (2:1) | ||
| 2nd (2nd leg) | CSD Comunicaciones | - | Deportivo Marquense | 3:0 (0:0) | ||
| 1st(1st leg): 29/11/2012 02:30 | 2nd (2nd leg): 02/12/2012 00:00 | Winner: CSD Comunicaciones | ||||
| 1st(1st leg) | Halcones FC | - | Deportivo Heredia | 3:1 (1:0) | ||
| 2nd (2nd leg) | Deportivo Heredia | - | Halcones FC | 5:1 (3:0) | ||
| 1st(1st leg): 29/11/2012 18:00 | 2nd (2nd leg): 02/12/2012 18:00 | Winner: Deportivo Heredia | ||||
| 1st(1st leg) | Xelaju MC | - | Deportivo Malacateco | 0:5 (0:1) | ||
| 2nd (2nd leg) | Deportivo Malacateco | - | Xelaju MC | 0:3 (0:1) | ||
| 1st(1st leg): 29/11/2012 21:00 | 2nd (2nd leg): 03/12/2012 00:00 | Winner: Deportivo Malacateco | ||||
