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| 1st(1st leg) | Marathón | - | Real España | 1:0 | ||
| 2nd (2nd leg) | Real España | - | Marathón | 2:0 | ||
| 1st(1st leg): 05/05/2016 22:30 | 2nd (2nd leg): 09/05/2016 02:00 | Winner: Real España | ||||
| 1st(1st leg) | Juticalpa | - | Motagua | 1:0 | ||
| 2nd (2nd leg) | Motagua | - | Juticalpa | 3:0 | ||
| 1st(1st leg): 06/05/2016 01:00 | 2nd (2nd leg): 08/05/2016 23:00 | Winner: Motagua | ||||
