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| 1st(1st leg) | Albinegros Orizaba | - | Indios Juárez | 1:0 (1:0) | ||
| 2nd (2nd leg) | Indios Juárez | - | Albinegros Orizaba | 0:1 (0:0) | ||
| 1st(1st leg): 18/11/2010 01:00 | 2nd (2nd leg): 21/11/2010 02:00 | Winner: Albinegros Orizaba | ||||
| 1st(1st leg) | Club Irapuato | - | Alacranes de Durango | 2:0 (0:0) | ||
| 2nd (2nd leg) | Alacranes de Durango | - | Club Irapuato | 3:2 (3:1) | ||
| 1st(1st leg): 18/11/2010 02:45 | 2nd (2nd leg): 21/11/2010 01:00 | Winner: Club Irapuato | ||||
| 1st(1st leg) | Veracruz (old) | - | Lobos BUAP | 1:1 (0:0) | ||
| 2nd (2nd leg) | Lobos BUAP | - | Veracruz (old) | 0:1 (0:1) | ||
| 1st(1st leg): 19/11/2010 01:00 | 2nd (2nd leg): 21/11/2010 23:00 | Winner: Veracruz (old) | ||||
