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| 1st(1st leg) | Atlético Reynosa | - | Loros UCOL | 0:2 | ||
| 2nd (2nd leg) | Loros UCOL | - | Atlético Reynosa | 2:0 | ||
| 1st(1st leg): 03/05/2018 01:30 | 2nd (2nd leg): 05/05/2018 22:00 | Winner: Loros UCOL | ||||
| 1st(1st leg) | Club Irapuato | - | Reboceros de La Piedad | 0:0 | ||
| 2nd (2nd leg) | Reboceros de La Piedad | - | Club Irapuato | 4:0 | ||
| 1st(1st leg): 03/05/2018 02:00 | 2nd (2nd leg): 06/05/2018 02:00 | Winner: Reboceros de La Piedad | ||||
