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| 1st(1st leg) | Monarcas Morelia | - | CF Monterrey | 1:0 | ||
| 2nd (2nd leg) | CF Monterrey | - | Monarcas Morelia | 3:2 | ||
| 1st(1st leg): 22/11/2017 16:00 | 2nd (2nd leg): 25/11/2017 16:00 | Winner: Monarcas Morelia | ||||
| 1st(1st leg) | Deportivo Guadalajara | - | CF Pachuca | 3:1 | ||
| 2nd (2nd leg) | CF Pachuca | - | Deportivo Guadalajara | 1:3 | ||
| 1st(1st leg): 22/11/2017 16:30 | 2nd (2nd leg): 25/11/2017 15:30 | Winner: Deportivo Guadalajara | ||||
| 1st(1st leg) | Club Necaxa | - | Santos Laguna | 0:0 | ||
| 2nd (2nd leg) | Santos Laguna | - | Club Necaxa | 1:0 | ||
| 1st(1st leg): 23/11/2017 15:00 | 2nd (2nd leg): 26/11/2017 15:00 | Winner: Santos Laguna | ||||
| 1st(1st leg) | CF América | - | Pumas UNAM | 0:0 | ||
| 2nd (2nd leg) | Pumas UNAM | - | CF América | 0:0 | ||
| 1st(1st leg): 23/11/2017 16:00 | 2nd (2nd leg): 26/11/2017 18:45 | |||||
