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| 1st(1st leg) | Club Necaxa | - | CF América | 0:2 | ||
| 2nd (2nd leg) | CF América | - | Club Necaxa | 0:0 | ||
| 1st(1st leg): 02/05/2018 15:00 | 2nd (2nd leg): 05/05/2018 15:00 | Winner: CF América | ||||
| 1st(1st leg) | CF Pachuca | - | Deportivo Guadalajara | 2:0 | ||
| 2nd (2nd leg) | Deportivo Guadalajara | - | CF Pachuca | 1:0 | ||
| 1st(1st leg): 02/05/2018 15:30 | 2nd (2nd leg): 05/05/2018 15:00 | Winner: CF Pachuca | ||||
| 1st(1st leg) | Pumas UNAM | - | Santos Laguna | 2:3 | ||
| 2nd (2nd leg) | Santos Laguna | - | Pumas UNAM | 2:3 | ||
| 1st(1st leg): 03/05/2018 16:00 | 2nd (2nd leg): 06/05/2018 15:00 | |||||
| 1st(1st leg) | UANL Tigres | - | Gallos Blancos | 2:0 | ||
| 2nd (2nd leg) | Gallos Blancos | - | UANL Tigres | 2:1 | ||
| 1st(1st leg): 03/05/2018 16:00 | 2nd (2nd leg): 06/05/2018 16:00 | Winner: UANL Tigres | ||||
