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| 1st(1st leg) | Deportivo Guadalajara | - | Puebla FC | 1:1 | ||
| 2nd (2nd leg) | Puebla FC | - | Deportivo Guadalajara | 2:3 | ||
| 1st(1st leg): 22/11/2017 22:00 | 2nd (2nd leg): 25/11/2017 18:00 | Winner: Deportivo Guadalajara | ||||
| 1st(1st leg) | Atlas Guadalajara | - | Pumas UNAM | 1:0 | ||
| 2nd (2nd leg) | Pumas UNAM | - | Atlas Guadalajara | 1:1 | ||
| 1st(1st leg): 23/11/2017 16:00 | 2nd (2nd leg): 26/11/2017 15:00 | Winner: Atlas Guadalajara | ||||
| 1st(1st leg) | Gallos Blancos | - | CF América | 2:1 | ||
| 2nd (2nd leg) | CF América | - | Gallos Blancos | 1:2 | ||
| 1st(1st leg): 23/11/2017 16:00 | 2nd (2nd leg): 26/11/2017 18:00 | Winner: Gallos Blancos | ||||
| 1st(1st leg) | Monarcas Morelia | - | Santos Laguna | 2:2 | ||
| 2nd (2nd leg) | Santos Laguna | - | Monarcas Morelia | 1:1 | ||
| 1st(1st leg): 23/11/2017 16:00 | 2nd (2nd leg): 26/11/2017 17:00 | Winner: Santos Laguna | ||||
