1. Round | 05/09/2021 | AD Ceuta FC | - | CF Villanovense | 2:3 | ||||
2. Round | 12/09/2021 | CF Villanovense | - | Vélez CF | 2:0 | ||||
3. Round | 19/09/2021 | Xerez DFC | - | CF Villanovense | 2:0 | ||||
4. Round | 26/09/2021 | CF Villanovense | - | Cádiz CF B | 1:1 | ||||
5. Round | 03/10/2021 | CD Coria | - | CF Villanovense | 0:0 | ||||
6. Round | 10/10/2021 | CF Villanovense | - | Don Benito | 0:2 | ||||
7. Round | 17/10/2021 | UD Tamaraceite | - | CF Villanovense | 0:1 | ||||
8. Round | 24/10/2021 | CF Villanovense | - | UD San Fernando | 2:0 | ||||
9. Round | 31/10/2021 | CD Mensajero | - | CF Villanovense | 1:0 | ||||
10. Round | 07/11/2021 | CF Villanovense | - | Antequera CF | 1:1 | ||||
11. Round | 13/11/2021 | CD San Roque | - | CF Villanovense | 2:0 | ||||
12. Round | 20/11/2021 | CF Villanovense | - | Córdoba CF | 1:0 | ||||
13. Round | 27/11/2021 | CP Cacereño | - | CF Villanovense | 0:1 |