1. Round | 05/09/2021 | Sestao River | - | CD Laredo | 2:0 | ||||
2. Round | 12/09/2021 | Real Sociedad C | - | Sestao River | 1:0 | ||||
3. Round | 19/09/2021 | Sestao River | - | AD San Juan | 2:1 | ||||
4. Round | 26/09/2021 | Arenas de Getxo | - | Sestao River | 1:1 | ||||
5. Round | 03/10/2021 | Sestao River | - | Burgos Promesas | 1:1 | ||||
6. Round | 10/10/2021 | Racing Rioja CF | - | Sestao River | 1:1 | ||||
7. Round | 17/10/2021 | Sestao River | - | CF Ardoi | 4:0 | ||||
8. Round | 23/10/2021 | Peña Sport FC | - | Sestao River | 0:0 | ||||
9. Round | 31/10/2021 | Sestao River | - | CD Cayón | 3:0 | ||||
10. Round | 06/11/2021 | Rayo Cantabria | - | Sestao River | 1:2 | ||||
11. Round | 14/11/2021 | Náxara CD | - | Sestao River | 2:1 | ||||
12. Round | 20/11/2021 | Sestao River | - | CA Osasuna B | 1:2 | ||||
13. Round | 27/11/2021 | SD Gernika | - | Sestao River | 0:2 | ||||
14. Round | 05/12/2021 | Sestao River | - | UD Logroñés Promesas | 2:1 | ||||
15. Round | 11/12/2021 | UD Mutilvera | - | Sestao River | 1:1 | ||||
30. Round | 16/04/2022 | Sestao River | - | SD Gernika | 3:2 | ||||
31. Round | 24/04/2022 | UD Logroñés Promesas | - | Sestao River | 1:1 |