5. Round | 04/03/2022 | General Caballero DJLM | - | Club Nacional | 1:2 | ||||
7. Round | 21/03/2022 | General Caballero DJLM | - | Guaireña FC | 0:1 | ||||
8. Round | 03/04/2022 | Sol de América | - | General Caballero DJLM | 2:3 | ||||
9. Round | 09/04/2022 | General Caballero DJLM | - | Cerro Porteño | 0:0 | ||||
10. Round | 18/04/2022 | Resistencia SC | - | General Caballero DJLM | 2:1 | ||||
11. Round | 20/04/2022 | General Caballero DJLM | - | 12 de Octubre de Itauguá | 0:0 | ||||
12. Round | 24/04/2022 | General Caballero DJLM | - | Club Olimpia | 2:3 | ||||
13. Round | 30/04/2022 | General Caballero DJLM | - | Libertad | 0:1 | ||||
14. Round | 07/05/2022 | Tacuary | - | General Caballero DJLM | 0:0 | ||||
15. Round | 10/05/2022 | General Caballero DJLM | - | Sportivo Ameliano | 0:3 | ||||
16. Round | 14/05/2022 | Club Nacional | - | General Caballero DJLM | 1:2 | ||||
17. Round | 22/05/2022 | General Caballero DJLM | - | Guaraní | 0:4 | ||||
18. Round | 12/06/2022 | Guaireña FC | - | General Caballero DJLM | 1:2 | ||||
19. Round | 17/06/2022 | General Caballero DJLM | - | Sol de América | 1:1 | ||||
22. Round | 03/07/2022 | 12 de Octubre de Itauguá | - | General Caballero DJLM | 1:3 |