 |
 |
|
| 01/07/2022 | 22:00 | Guaireña FC | - | Club Nacional | 1:1 (1:1) | |
| 02/07/2022 | 00:15 | Sol de América | - | Sportivo Ameliano | 0:1 (0:0) | |
| 22:00 | Cerro Porteño | - | Tacuary | 1:0 (0:0) | ||
| 03/07/2022 | 00:15 | Resistencia SC | - | Libertad | 0:4 (0:3) | |
| 21:00 | 12 de Octubre de Itauguá | - | General Caballero DJLM | 1:3 (0:3) | ||
| 23:15 | Guaraní | - | Club Olimpia | 0:2 (0:1) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Libertad | 22 | 18 | 3 | 1 | 49:14 | 35 | 57 |
| 2 |
|
Cerro Porteño | 22 | 16 | 2 | 4 | 38:13 | 25 | 50 |
| 3 |
|
Club Olimpia | 22 | 13 | 4 | 5 | 41:23 | 18 | 43 |
| 4 |
|
Guaraní | 22 | 9 | 5 | 8 | 30:24 | 6 | 32 |
| 5 |
|
Resistencia SC | 22 | 7 | 7 | 8 | 30:36 | -6 | 28 |
| 6 |
|
Club Nacional | 22 | 7 | 5 | 10 | 27:32 | -5 | 26 |
| 7 |
|
Sol de América | 22 | 6 | 7 | 9 | 20:28 | -8 | 25 |
| 8 |
|
Guaireña FC | 22 | 5 | 8 | 9 | 21:26 | -5 | 23 |
| 9 |
|
General Caballero DJLM | 22 | 6 | 5 | 11 | 23:33 | -10 | 23 |
| 10 |
|
Tacuary | 22 | 6 | 4 | 12 | 16:29 | -13 | 22 |
| 11 |
|
Sportivo Ameliano | 22 | 5 | 4 | 13 | 25:38 | -13 | 19 |
| 12 |
|
12 de Octubre de Itauguá | 22 | 3 | 8 | 11 | 16:40 | -24 | 17 |
| Copa Libertadores |
