1. Round | 04/02/2022 | Club Olimpia | - | General Caballero DJLM | 2:2 | ||||
2. Round | 12/02/2022 | Libertad | - | General Caballero DJLM | 1:0 | ||||
3. Round | 19/02/2022 | General Caballero DJLM | - | Tacuary | 2:0 | ||||
4. Round | 25/02/2022 | Sportivo Ameliano | - | General Caballero DJLM | 1:0 | ||||
5. Round | 04/03/2022 | General Caballero DJLM | - | Club Nacional | 1:2 | ||||
18. Round | 12/06/2022 | Guaireña FC | - | General Caballero DJLM | 1:2 | ||||
19. Round | 17/06/2022 | General Caballero DJLM | - | Sol de América | 1:1 | ||||
20. Round | 21/06/2022 | Cerro Porteño | - | General Caballero DJLM | 3:1 | ||||
21. Round | 25/06/2022 | General Caballero DJLM | - | Resistencia SC | 2:1 | ||||
22. Round | 03/07/2022 | 12 de Octubre de Itauguá | - | General Caballero DJLM | 1:3 |