1. Round | 25/07/2021 | KV Mechelen | - | Royal Antwerp FC | 3:2 | ||||
2. Round | 31/07/2021 | RFC Seraing | - | KV Mechelen | 1:0 | ||||
3. Round | 07/08/2021 | KV Mechelen | - | KAS Eupen | 1:3 | ||||
4. Round | 15/08/2021 | KAA Gent | - | KV Mechelen | 2:0 | ||||
5. Round | 22/08/2021 | KV Mechelen | - | Union Saint-Gilloise | 3:1 | ||||
7. Round | 12/09/2021 | RSC Anderlecht | - | KV Mechelen | 7:2 | ||||
8. Round | 18/09/2021 | KV Mechelen | - | Oud-Heverlee Leuven | 2:0 | ||||
9. Round | 26/09/2021 | Sporting Charleroi | - | KV Mechelen | 0:2 | ||||
10. Round | 01/10/2021 | KV Mechelen | - | Standard Liège | 3:1 | ||||
11. Round | 17/10/2021 | K Beerschot VA | - | KV Mechelen | 0:1 | ||||
13. Round | 29/10/2021 | KV Oostende | - | KV Mechelen | 2:4 | ||||
14. Round | 06/11/2021 | KV Mechelen | - | Sint-Truidense VV | 0:1 | ||||
21. Round | 27/12/2021 | KV Mechelen | - | RFC Seraing | 2:0 | ||||
23. Round | 23/01/2022 | KV Mechelen | - | RSC Anderlecht | 0:1 |