1. Round | 14/08/2021 | Fortuna Sittard | - | FC Twente | 2:1 | ||||
2. Round | 22/08/2021 | FC Twente | - | AFC Ajax | 1:1 | ||||
3. Round | 28/08/2021 | SC Cambuur | - | FC Twente | 2:0 | ||||
6. Round | 23/09/2021 | FC Twente | - | AZ Alkmaar | 3:1 | ||||
8. Round | 01/10/2021 | FC Groningen | - | FC Twente | 1:1 | ![]() |
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9. Round | 17/10/2021 | FC Twente | - | Willem II | 1:1 | ||||
10. Round | 24/10/2021 | FC Twente | - | NEC Nijmegen | 1:2 | ||||
12. Round | 05/11/2021 | FC Twente | - | Heracles Almelo | 1:0 | ||||
13. Round | 20/11/2021 | Sparta Rotterdam | - | FC Twente | 0:1 | ||||
14. Round | 28/11/2021 | FC Twente | - | Feyenoord | 0:0 | ||||
15. Round | 05/12/2021 | Go Ahead Eagles | - | FC Twente | 1:2 | ||||
16. Round | 12/12/2021 | FC Twente | - | RKC Waalwijk | 2:1 | ||||
18. Round | 22/12/2021 | FC Utrecht | - | FC Twente | 1:1 | ![]() |
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19. Round | 15/01/2022 | FC Twente | - | sc Heerenveen | 2:0 |