1. Round | 05/02/2022 | Resistencia SC | - | Tacuary | 1:0 | ||||
2. Round | 11/02/2022 | Sportivo Ameliano | - | Resistencia SC | 1:4 | ||||
3. Round | 18/02/2022 | Resistencia SC | - | Club Nacional | 3:1 | ||||
4. Round | 26/02/2022 | Guaraní | - | Resistencia SC | 3:3 | ||||
5. Round | 05/03/2022 | Resistencia SC | - | Guaireña FC | 2:2 | ||||
6. Round | 12/03/2022 | Sol de América | - | Resistencia SC | 1:1 | ||||
8. Round | 02/04/2022 | Resistencia SC | - | Club Olimpia | 2:1 | ||||
9. Round | 08/04/2022 | 12 de Octubre de Itauguá | - | Resistencia SC | 1:1 | ||||
10. Round | 18/04/2022 | Resistencia SC | - | General Caballero DJLM | 2:1 | ||||
12. Round | 25/04/2022 | Tacuary | - | Resistencia SC | 3:1 | ||||
15. Round | 12/05/2022 | Resistencia SC | - | Guaraní | 1:2 | ||||
20. Round | 22/06/2022 | Resistencia SC | - | 12 de Octubre de Itauguá | 0:1 | ||||
22. Round | 03/07/2022 | Resistencia SC | - | Libertad | 0:4 |