1. Round | 17/07/2021 | 12 de Octubre de Itauguá | - | Club Nacional | 2:2 | ||||
13. Round | 25/10/2021 | Libertad | - | Club Nacional | 1:2 | ||||
14. Round | 29/10/2021 | Club Nacional | - | River Plate | 1:1 | ||||
15. Round | 08/11/2021 | Guaireña FC | - | Club Nacional | 0:0 | ||||
16. Round | 21/11/2021 | Club Nacional | - | Cerro Porteño | 1:5 | ||||
17. Round | 26/11/2021 | Sol de América | - | Club Nacional | 3:0 | ||||
18. Round | 05/12/2021 | Club Nacional | - | Club Olimpia | 1:3 |