 |
 |
|
| 03/12/2021 | 22:30 | Libertad | - | River Plate | 5:0 (2:0) | |
| 04/12/2021 | 21:15 | 12 de Octubre de Itauguá | - | Sol de América | 1:0 (0:0) | |
| 21:15 | Sportivo Luqueño | - | Guaireña FC | 0:1 (0:0) | ||
| 23:30 | Guaraní | - | Cerro Porteño | 2:2 (1:0) | ||
| 05/12/2021 | 22:30 | Club Nacional | - | Club Olimpia | 1:3 (1:1) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Cerro Porteño | 18 | 11 | 5 | 2 | 27:8 | 19 | 38 |
| 2 |
|
Guaraní | 18 | 10 | 6 | 2 | 39:19 | 20 | 36 |
| 3 |
|
Sol de América | 18 | 8 | 4 | 6 | 22:22 | 0 | 28 |
| 4 |
|
Libertad | 18 | 7 | 6 | 5 | 32:21 | 11 | 27 |
| 5 |
|
12 de Octubre de Itauguá | 18 | 5 | 6 | 7 | 18:22 | -4 | 21 |
| 6 |
|
Sportivo Luqueño | 18 | 5 | 6 | 7 | 16:27 | -11 | 21 |
| 7 |
|
Club Nacional | 18 | 4 | 8 | 6 | 17:25 | -8 | 20 |
| 8 |
|
Club Olimpia | 18 | 6 | 0 | 12 | 24:29 | -5 | 18 |
| 9 |
|
Guaireña FC | 18 | 4 | 6 | 8 | 12:21 | -9 | 18 |
| 10 |
|
River Plate | 18 | 4 | 5 | 9 | 15:28 | -13 | 17 |
| 11 |
|
Deportivo Recoleta | 0 | 0 | 0 | 0 | 0:0 | 0 | 0 |
| Copa Libertadores |
