1. Round | 27/08/2021 | CD Leonesa | - | Rayo Majadahonda | 0:2 | ||||
2. Round | 05/09/2021 | Unionistas CF | - | CD Leonesa | 2:2 | ||||
3. Round | 12/09/2021 | CD Leonesa | - | Athletic Bilbao B | 2:1 | ||||
4. Round | 19/09/2021 | Inter de Madrid | - | CD Leonesa | 3:2 | ||||
6. Round | 02/10/2021 | CD Badajoz | - | CD Leonesa | 3:3 | ||||
7. Round | 09/10/2021 | CD Leonesa | - | CF Talavera | 1:2 | ||||
8. Round | 16/10/2021 | CD Leonesa | - | Extremadura UD | 2:1 | ||||
9. Round | 23/10/2021 | Racing Ferrol | - | CD Leonesa | 1:1 | ||||
10. Round | 30/10/2021 | CD Tudelano | - | CD Leonesa | 1:1 | ||||
11. Round | 07/11/2021 | CD Leonesa | - | Racing Santander | 3:0 |