2. Round | 24/07/2021 | Club Nacional | - | Guaraní | 1:1 | ||||
3. Round | 31/07/2021 | Sportivo Luqueño | - | Club Nacional | 2:1 | ||||
4. Round | 07/08/2021 | Club Nacional | - | Libertad | 1:0 | ||||
5. Round | 14/08/2021 | River Plate | - | Club Nacional | 1:0 | ||||
8. Round | 11/09/2021 | Club Nacional | - | Sol de América | 1:1 | ||||
9. Round | 21/09/2021 | Club Olimpia | - | Club Nacional | 1:2 | ||||
10. Round | 25/09/2021 | Club Nacional | - | 12 de Octubre de Itauguá | 1:1 | ||||
11. Round | 03/10/2021 | Guaraní | - | Club Nacional | 1:1 | ||||
16. Round | 21/11/2021 | Club Nacional | - | Cerro Porteño | 1:5 | ||||
17. Round | 26/11/2021 | Sol de América | - | Club Nacional | 3:0 | ||||
18. Round | 05/12/2021 | Club Nacional | - | Club Olimpia | 1:3 |