1. Round | 26/07/2015 | Santos Laguna | - | Club León | 1:3 | ||||
2. Round | 02/08/2015 | Chiapas FC | - | Santos Laguna | 2:1 | ||||
3. Round | 08/08/2015 | Santos Laguna | - | Club Tijuana | 0:1 | ||||
7. Round | 29/08/2015 | Santos Laguna | - | Pumas UNAM | 3:4 | ||||
13. Round | 17/10/2015 | CD Veracruz | - | Santos Laguna | 0:3 | ||||
14. Round | 24/10/2015 | Santos Laguna | - | Cruz Azul | 1:2 | ||||
15. Round | 01/11/2015 | UANL Tigres | - | Santos Laguna | 2:2 | ||||
16. Round | 07/11/2015 | Santos Laguna | - | Monarcas Morelia | 2:3 | ||||
17. Round | 22/11/2015 | Deportivo Guadalajara | - | Santos Laguna | 0:3 |