1. Round | 15/08/2021 | SC Cambuur | - | FC Groningen | 1:2 | ||||
2. Round | 21/08/2021 | FC Groningen | - | FC Utrecht | 0:0 | ||||
3. Round | 28/08/2021 | PSV Eindhoven | - | FC Groningen | 5:2 | ||||
4. Round | 12/09/2021 | FC Groningen | - | sc Heerenveen | 1:1 | ||||
5. Round | 18/09/2021 | Willem II | - | FC Groningen | 2:1 | ||||
7. Round | 25/09/2021 | AFC Ajax | - | FC Groningen | 3:0 | ||||
11. Round | 31/10/2021 | NEC Nijmegen | - | FC Groningen | 3:0 | ||||
12. Round | 07/11/2021 | FC Groningen | - | RKC Waalwijk | 1:1 | ||||
13. Round | 21/11/2021 | Go Ahead Eagles | - | FC Groningen | 0:1 | ||||
17. Round | 18/12/2021 | Heracles Almelo | - | FC Groningen | 4:2 |