1. Round | 23/07/2021 | FC Schalke 04 | - | Hamburger SV | 1:3 | ||||
2. Round | 01/08/2021 | Holstein Kiel | - | FC Schalke 04 | 0:3 | ||||
4. Round | 21/08/2021 | Jahn Regensburg | - | FC Schalke 04 | 4:1 | ||||
5. Round | 28/08/2021 | FC Schalke 04 | - | Fortuna Düsseldorf | 3:1 | ||||
9. Round | 03/10/2021 | FC Schalke 04 | - | FC Ingolstadt 04 | 3:0 | ||||
10. Round | 15/10/2021 | Hannover 96 | - | FC Schalke 04 | 0:1 | ||||
11. Round | 23/10/2021 | FC Schalke 04 | - | Dynamo Dresden | 3:0 | ||||
12. Round | 29/10/2021 | 1. FC Heidenheim 1846 | - | FC Schalke 04 | 1:0 | ||||
15. Round | 27/11/2021 | FC Schalke 04 | - | SV Sandhausen | 5:2 | ||||
16. Round | 04/12/2021 | FC St. Pauli | - | FC Schalke 04 | 2:1 | ||||
17. Round | 10/12/2021 | FC Schalke 04 | - | 1. FC Nürnberg | 4:1 | ||||
18. Round | 18/12/2021 | Hamburger SV | - | FC Schalke 04 | 1:1 | ||||
19. Round | 16/01/2022 | FC Schalke 04 | - | Holstein Kiel | 1:1 | ||||
21. Round | 05/02/2022 | FC Schalke 04 | - | Jahn Regensburg | 2:1 | ||||
26. Round | 13/03/2022 | FC Ingolstadt 04 | - | FC Schalke 04 | 0:3 |