1. Round | 25/07/2021 | Spartak Trnava | - | FK Pohronie | 2:0 | ||||
2. Round | 01/08/2021 | FK Senica | - | Spartak Trnava | 2:1 | ||||
3. Round | 09/08/2021 | Spartak Trnava | - | Tatran Liptovský Mikuláš | 4:0 | ||||
4. Round | 15/08/2021 | Spartak Trnava | - | Zlaté Moravce | 2:0 | ||||
5. Round | 21/08/2021 | MFK Ružomberok | - | Spartak Trnava | 0:0 | ||||
6. Round | 29/08/2021 | Spartak Trnava | - | MŠK Žilina | 1:1 | ||||
7. Round | 11/09/2021 | MFK Zemplín Michalovce | - | Spartak Trnava | 1:2 | ||||
8. Round | 17/09/2021 | Spartak Trnava | - | ŠKF Sereď | 2:0 | ||||
9. Round | 26/09/2021 | FC DAC 1904 | - | Spartak Trnava | 0:3 | ||||
10. Round | 03/10/2021 | AS Trenčín | - | Spartak Trnava | 0:1 | ||||
16. Round | 28/11/2021 | Spartak Trnava | - | MFK Ružomberok | 0:3 | ||||
17. Round | 05/12/2021 | MŠK Žilina | - | Spartak Trnava | 0:1 | ||||
18. Round | 10/12/2021 | Spartak Trnava | - | MFK Zemplín Michalovce | 2:0 | ||||
19. Round | 18/12/2021 | ŠKF Sereď | - | Spartak Trnava | 0:1 | ||||
21. Round | 19/02/2022 | Spartak Trnava | - | AS Trenčín | 0:0 | ||||
22. Round | 26/02/2022 | Slovan Bratislava | - | Spartak Trnava | 0:0 |