4. Round | 15/08/2021 | FK Mashuk KMV | - | FK Biolog Novokubansk | 2:0 | ||||
5. Round | 18/08/2021 | FK Biolog Novokubansk | - | Spartak Nalchik | 1:0 | ||||
6. Round | 29/08/2021 | FK Chayka | - | FK Biolog Novokubansk | 2:1 | ||||
7. Round | 04/09/2021 | FK Biolog Novokubansk | - | Anzhi Makhachkala | 0:2 | ||||
8. Round | 08/09/2021 | FK Druzhba | - | FK Biolog Novokubansk | 1:1 | ||||
9. Round | 12/09/2021 | FK Biolog Novokubansk | - | Alania-2 Vladikavkaz | 5:3 | ||||
11. Round | 26/09/2021 | FK Biolog Novokubansk | - | Forte Taganrog | 0:0 | ||||
12. Round | 03/10/2021 | FK Dinamo Makhachkala | - | FK Biolog Novokubansk | 2:0 | ||||
13. Round | 10/10/2021 | FK Biolog Novokubansk | - | Rotor-2 Volgograd | 3:0 | ||||
14. Round | 18/10/2021 | FK Tuapse | - | FK Biolog Novokubansk | 0:3 dec. | ||||
16. Round | 31/10/2021 | Dinamo Stavropol | - | FK Biolog Novokubansk | 1:0 | ||||
17. Round | 06/11/2021 | FK Biolog Novokubansk | - | Chernomorets Novorossisk | 2:2 |