1. Round 13/08/2000 Samsunspor - MKE Ankaragücü 3:0
3. Round 25/08/2000 Samsunspor - Trabzonspor 1:1
4. Round 09/09/2000 Galatasaray - Samsunspor 1:2
5. Round 16/09/2000 Samsunspor - Erzurumspor (1968-2015) 2:2
6. Round 23/09/2000 Bursaspor - Samsunspor 0:2
8. Round 15/10/2000 Samsunspor - Kocaelispor 3:0 dec.
10. Round 29/10/2000 Samsunspor - Gençlerbirliği 1:2
11. Round 05/11/2000 Siirt Jetpa Spor - Samsunspor 1:2 yellow card
12. Round 12/11/2000 Samsunspor - Beşiktaş 2:3
13. Round 19/11/2000 Yozgatspor - Samsunspor 0:0
14. Round 25/11/2000 Samsunspor - Antalyaspor 4:2
15. Round 03/12/2000 Çaykur Rizespor - Samsunspor 0:1
16. Round 09/12/2000 Samsunspor - Adanaspor 3:1
17. Round 15/12/2000 Fenerbahçe - Samsunspor 2:1
19. Round 02/02/2001 Samsunspor - Gaziantepspor 3:3
20. Round 09/02/2001 Trabzonspor - Samsunspor 3:2
21. Round 17/02/2001 Samsunspor - Galatasaray 1:1
22. Round 25/02/2001 Erzurumspor (1968-2015) - Samsunspor 1:2
23. Round 03/03/2001 Samsunspor - Bursaspor 2:0
24. Round 10/03/2001 Samsunspor - Denizlispor 2:1
25. Round 16/03/2001 Kocaelispor - Samsunspor 1:0
26. Round 01/04/2001 Samsunspor - İstanbulspor AŞ 2:3
27. Round 07/04/2001 Gençlerbirliği - Samsunspor 1:0
28. Round 14/04/2001 Samsunspor - Siirt Jetpa Spor 4:3 Goal
29. Round 20/04/2001 Beşiktaş - Samsunspor 0:0
30. Round 29/04/2001 Samsunspor - Yozgatspor 0:2
31. Round 05/05/2001 Antalyaspor - Samsunspor 2:2
32. Round 12/05/2001 Samsunspor - Çaykur Rizespor 1:1
33. Round 19/05/2001 Adanaspor - Samsunspor 3:5
34. Round 26/05/2001 Samsunspor - Fenerbahçe 1:3