5. Round | 18/09/2021 | Willem II | - | FC Groningen | 2:1 | ||||
7. Round | 25/09/2021 | Willem II | - | PSV Eindhoven | 2:1 | ||||
15. Round | 02/12/2021 | AFC Ajax | - | Willem II | 5:0 | ||||
17. Round | 18/12/2021 | AZ Alkmaar | - | Willem II | 4:1 | ||||
19. Round | 14/01/2022 | PEC Zwolle | - | Willem II | 2:0 |