4. Round | 09/08/2021 | Sol de América | - | River Plate | 1:0 | ||||
14. Round | 29/10/2021 | Club Nacional | - | River Plate | 1:1 | ||||
15. Round | 05/11/2021 | River Plate | - | 12 de Octubre de Itauguá | 0:2 | ||||
16. Round | 20/11/2021 | Guaraní | - | River Plate | 2:1 | ||||
17. Round | 26/11/2021 | River Plate | - | Sportivo Luqueño | 0:0 | ||||
18. Round | 03/12/2021 | Libertad | - | River Plate | 5:0 |