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| 12/01/2008 | 19:00 | RAEC Mons | - | KAA Gent | 0:1 aet | |
| 19:00 | RSC Anderlecht | - | KV Red Star Waasland | 2:0 | ||
| 19:00 | Germinal Beerschot | - | Oud-Heverlee Leuven | 3:1 pso | ||
| 19:30 | KV Kortrijk | - | SV Zulte Waregem | 2:1 aet | ||
| 13/01/2008 | 14:00 | FCV Dender EH | - | Eendracht Aalst | 2:1 | |
| 15:00 | KSV Roeselare | - | Sporting Charleroi | 5:4 pso | ||
| 14/01/2008 | 19:30 | Standard Liège | - | KRC Genk | 2:0 | |
| 19:45 | Cercle Brugge | - | Club Brugge KV | 1:0 |
