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| 17/02/2006 | 19:30 | RSC Anderlecht | - | FC Brussels | 2:0 (1:0) | |
| 18/02/2006 | 17:00 | SV Zulte Waregem | - | KRC Genk | 1:0 (1:0) | |
| 19:00 | Standard Liège | - | Cercle Brugge | 7:1 (4:0) | ||
| 19:00 | KAA Gent | - | Excelsior Mouscron | 0:0 (0:0) | ||
| 19:00 | Sporting Charleroi | - | Lierse SK | 0:1 (0:1) | ||
| 19:00 | Sporting Lokeren | - | Sint-Truidense VV | 1:2 (1:1) | ||
| 19:00 | KVC Westerlo | - | KSV Roeselare | 3:2 (1:1) | ||
| 19/02/2006 | 17:00 | Club Brugge KV | - | KSK Beveren | 1:0 (1:0) | |
| 19:30 | RAA La Louviére | - | Germinal Beerschot | 1:1 (0:0) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
RSC Anderlecht | 23 | 13 | 7 | 3 | 49:22 | 27 | 46 |
| 2 |
|
Standard Liège | 23 | 14 | 4 | 5 | 41:21 | 20 | 46 |
| 3 |
|
Club Brugge KV | 23 | 13 | 7 | 3 | 38:21 | 17 | 46 |
| 4 |
|
SV Zulte Waregem | 23 | 12 | 4 | 7 | 42:34 | 8 | 40 |
| 5 |
|
KRC Genk | 23 | 10 | 7 | 6 | 37:29 | 8 | 37 |
| 6 |
|
KVC Westerlo | 23 | 10 | 5 | 8 | 31:27 | 4 | 35 |
| 7 |
|
KAA Gent | 23 | 10 | 5 | 8 | 30:27 | 3 | 35 |
| 8 |
|
FC Brussels | 23 | 8 | 8 | 7 | 25:24 | 1 | 32 |
| 9 |
|
Sporting Lokeren | 23 | 8 | 8 | 7 | 32:33 | -1 | 32 |
| 10 |
|
Sporting Charleroi | 23 | 8 | 6 | 9 | 22:28 | -6 | 30 |
| 11 |
|
KSV Roeselare | 23 | 7 | 8 | 8 | 37:30 | 7 | 29 |
| 12 |
|
Germinal Beerschot | 23 | 8 | 4 | 11 | 31:37 | -6 | 28 |
| 13 |
|
Cercle Brugge | 23 | 7 | 4 | 12 | 29:43 | -14 | 25 |
| 14 |
|
Excelsior Mouscron | 23 | 7 | 3 | 13 | 31:35 | -4 | 24 |
| 15 |
|
Sint-Truidense VV | 23 | 5 | 7 | 11 | 24:34 | -10 | 22 |
| 16 |
|
KSK Beveren | 23 | 6 | 3 | 14 | 25:37 | -12 | 21 |
| 17 |
|
RAA La Louviére | 23 | 4 | 9 | 10 | 21:40 | -19 | 21 |
| 18 |
|
Lierse SK | 23 | 4 | 7 | 12 | 14:37 | -23 | 19 |
