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| 1st(1st leg) | Bolívar | - | The Strongest | 1:0 (0:0) | ||
| 2nd (2nd leg) | The Strongest | - | Bolívar | 4:0 (1:0) | ||
| 1st(1st leg): 04/12/2011 00:00 | 2nd (2nd leg): 08/12/2011 00:00 | Winner: The Strongest | ||||
| 1st(1st leg) | San José | - | Club Aurora | 1:0 (0:0) | ||
| 2nd (2nd leg) | Club Aurora | - | San José | 0:2 (0:1) | ||
| 1st(1st leg): 04/12/2011 19:00 | 2nd (2nd leg): 08/12/2011 00:00 | Winner: San José | ||||
| 1st(1st leg) | Nacional Potosí | - | Universitario de Sucre | 2:3 (1:1) | ||
| 2nd (2nd leg) | Universitario de Sucre | - | Nacional Potosí | 1:0 (0:0) | ||
| 1st(1st leg): 04/12/2011 21:00 | 2nd (2nd leg): 08/12/2011 00:00 | Winner: Universitario de Sucre | ||||
| 1st(1st leg) | CD Guabirá | - | Oriente Petrolero | 0:0 (0:0) | ||
| 2nd (2nd leg) | Oriente Petrolero | - | CD Guabirá | 4:1 (2:1) | ||
| 1st(1st leg): 05/12/2011 00:00 | 2nd (2nd leg): 08/12/2011 00:30 | Winner: Oriente Petrolero | ||||
