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| 1st(1st leg) | CSA - AL | - | América - MG | 0:3 (0:0) | ||
| 2nd (2nd leg) | América - MG | - | CSA - AL | 2:0 (1:0) | ||
| 1st(1st leg): 19/04/2022 23:00 | 2nd (2nd leg): 10/05/2022 23:00 | Winner: América - MG | ||||
| 1st(1st leg) | Bahia - BA | - | Azuriz - PR | 0:0 (0:0) | ||
| 2nd (2nd leg) | Azuriz - PR | - | Bahia - BA | 3:4 (1:0, 1:1) pso | ||
| 1st(1st leg): 19/04/2022 23:30 | 2nd (2nd leg): 11/05/2022 00:30 | Winner: Bahia - BA | ||||
| 1st(1st leg) | Fluminense RJ | - | Vila Nova - GO | 3:2 (0:1) | ||
| 2nd (2nd leg) | Vila Nova - GO | - | Fluminense RJ | 0:2 (0:1) | ||
| 1st(1st leg): 20/04/2022 01:30 | 2nd (2nd leg): 12/05/2022 01:30 | Winner: Fluminense RJ | ||||
| 1st(1st leg) | Remo - PA | - | Cruzeiro | 2:1 (0:0) | ||
| 2nd (2nd leg) | Cruzeiro | - | Remo - PA | 5:4 (0:0, 1:0) pso | ||
| 1st(1st leg): 20/04/2022 01:30 | 2nd (2nd leg): 12/05/2022 23:30 | Winner: Cruzeiro | ||||
| 1st(1st leg) | Goiás - GO | - | Red Bull Bragantino | 1:2 (1:1) | ||
| 2nd (2nd leg) | Red Bull Bragantino | - | Goiás - GO | 8:9 (0:1, 0:1) pso | ||
| 1st(1st leg): 20/04/2022 23:00 | 2nd (2nd leg): 01/06/2022 01:30 | Winner: Goiás - GO | ||||
| 1st(1st leg) | Atlético Mineiro | - | Brasiliense - DF | 3:0 (3:0) | ||
| 2nd (2nd leg) | Brasiliense - DF | - | Atlético Mineiro | 0:1 (0:1) | ||
| 1st(1st leg): 20/04/2022 23:00 | 2nd (2nd leg): 22/05/2022 23:00 | Winner: Atlético Mineiro | ||||
| 1st(1st leg) | Fortaleza - CE | - | Vitória - BA | 3:0 (2:0) | ||
| 2nd (2nd leg) | Vitória - BA | - | Fortaleza - CE | 0:1 (0:0) | ||
| 1st(1st leg): 20/04/2022 23:00 | 2nd (2nd leg): 12/05/2022 23:00 | Winner: Fortaleza - CE | ||||
| 1st(1st leg) | Tocantinópolis - TO | - | Athletico Paranaense | 2:5 (1:2) | ||
| 2nd (2nd leg) | Athletico Paranaense | - | Tocantinópolis - TO | 4:0 (3:0) | ||
| 1st(1st leg): 20/04/2022 23:00 | 2nd (2nd leg): 11/05/2022 01:30 | Winner: Athletico Paranaense | ||||
| 1st(1st leg) | Juventude - RS | - | São Paulo FC | 2:2 (2:0) | ||
| 2nd (2nd leg) | São Paulo FC | - | Juventude - RS | 2:0 (1:0) | ||
| 1st(1st leg): 20/04/2022 23:30 | 2nd (2nd leg): 12/05/2022 23:30 | Winner: São Paulo FC | ||||
| 1st(1st leg) | Coritiba - PR | - | Santos FC | 1:0 (1:0) | ||
| 2nd (2nd leg) | Santos FC | - | Coritiba - PR | 3:0 (0:0) | ||
| 1st(1st leg): 20/04/2022 23:30 | 2nd (2nd leg): 13/05/2022 01:30 | Winner: Santos FC | ||||
| 1st(1st leg) | Tombense - MG | - | Ceará - CE | 0:2 (0:1) | ||
| 2nd (2nd leg) | Ceará - CE | - | Tombense - MG | 2:0 (1:0) | ||
| 1st(1st leg): 21/04/2022 01:30 | 2nd (2nd leg): 11/05/2022 23:00 | Winner: Ceará - CE | ||||
| 1st(1st leg) | Portuguesa - RJ | - | Corinthians SP | 1:1 (1:1) | ||
| 2nd (2nd leg) | Corinthians SP | - | Portuguesa - RJ | 2:0 (2:0) | ||
| 1st(1st leg): 21/04/2022 01:30 | 2nd (2nd leg): 12/05/2022 01:30 | Winner: Corinthians SP | ||||
| 1st(1st leg) | Ceilândia - DF | - | Botafogo - RJ | 0:3 (0:1) | ||
| 2nd (2nd leg) | Botafogo - RJ | - | Ceilândia - DF | 3:0 (1:0) | ||
| 1st(1st leg): 21/04/2022 01:30 | 2nd (2nd leg): 13/05/2022 01:30 | Winner: Botafogo - RJ | ||||
| 1st(1st leg) | Atlético Goianiense | - | Cuiabá - MT | 1:1 (0:0) | ||
| 2nd (2nd leg) | Cuiabá - MT | - | Atlético Goianiense | 3:5 (0:0, 0:0) pso | ||
| 1st(1st leg): 22/04/2022 01:30 | 2nd (2nd leg): 12/05/2022 02:00 | Winner: Atlético Goianiense | ||||
| 1st(1st leg) | Palmeiras | - | Juazeirense - BA | 2:1 (1:1) | ||
| 2nd (2nd leg) | Juazeirense - BA | - | Palmeiras | 1:2 (0:1) | ||
| 1st(1st leg): 01/05/2022 01:00 | 2nd (2nd leg): 11/05/2022 23:00 | Winner: Palmeiras | ||||
| 1st(1st leg) | Altos - PI | - | Flamengo RJ | 1:2 (0:0) | ||
| 2nd (2nd leg) | Flamengo RJ | - | Altos - PI | 2:0 (0:0) | ||
| 1st(1st leg): 01/05/2022 22:00 | 2nd (2nd leg): 11/05/2022 23:30 | Winner: Flamengo RJ | ||||
