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| 1st(1st leg) | Zamalek | - | St. George SC | 1:1 | ||
| 2nd (2nd leg) | St. George SC | - | Zamalek | 2:2 | ||
| 1st(1st leg): 20/04/2013 18:00 | 2nd (2nd leg): 05/05/2013 14:30 | Winner: Zamalek | ||||
| 1st(1st leg) | JSM Béjaïa | - | Espérance de Tunis | 0:0 | ||
| 2nd (2nd leg) | Espérance de Tunis | - | JSM Béjaïa | 1:0 (0:0) | ||
| 1st(1st leg): 20/04/2013 18:00 | 2nd (2nd leg): 04/05/2013 16:00 | Winner: Espérance de Tunis | ||||
| 1st(1st leg) | Orlando Pirates | - | TP Mazembe | 3:1 | ||
| 2nd (2nd leg) | TP Mazembe | - | Orlando Pirates | 1:0 | ||
| 1st(1st leg): 20/04/2013 19:15 | 2nd (2nd leg): 05/05/2013 14:30 | Winner: Orlando Pirates | ||||
| 1st(1st leg) | CA Bizertin | - | Al Ahly SC | 0:0 | ||
| 2nd (2nd leg) | Al Ahly SC | - | CA Bizertin | 2:1 | ||
| 1st(1st leg): 21/04/2013 15:00 | 2nd (2nd leg): 05/05/2013 18:00 | Winner: Al Ahly SC | ||||
| 1st(1st leg) | Coton Sport Garoua | - | Stade Malien | 3:0 | ||
| 2nd (2nd leg) | Stade Malien | - | Coton Sport Garoua | 0:0 | ||
| 1st(1st leg): 21/04/2013 15:30 | 2nd (2nd leg): 04/05/2013 17:00 | Winner: Coton Sport Garoua | ||||
| 1st(1st leg) | AC Léopards | - | ES Sétif | 3:1 | ||
| 2nd (2nd leg) | ES Sétif | - | AC Léopards | 3:2 pso | ||
| 1st(1st leg): 21/04/2013 15:30 | 2nd (2nd leg): 03/05/2013 18:00 | Winner: ES Sétif | ||||
| 1st(1st leg) | Enugu Rangers | - | CRD Libolo | 0:0 | ||
| 2nd (2nd leg) | CRD Libolo | - | Enugu Rangers | 3:1 | ||
| 1st(1st leg): 21/04/2013 16:00 | 2nd (2nd leg): 04/05/2013 15:00 | Winner: CRD Libolo | ||||
| 1st(1st leg) | FUS de Rabat | - | Séwé Sport | 1:1 | ||
| 2nd (2nd leg) | Séwé Sport | - | FUS de Rabat | 0:0 | ||
| 1st(1st leg): 21/04/2013 20:00 | 2nd (2nd leg): 04/05/2013 16:30 | Winner: Séwé Sport | ||||
