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| 1st(1st leg) | Huachipato | - | Universidad de Concepción | 0:1 (0:1) | ||
| 2nd (2nd leg) | Universidad de Concepción | - | Huachipato | 2:1 (1:0) | ||
| 1st(1st leg): 07/10/2015 00:00 | 2nd (2nd leg): 11/10/2015 20:00 | Winner: Universidad de Concepción | ||||
| 1st(1st leg) | Audax Italiano | - | Unión Española | 1:0 (0:0) | ||
| 2nd (2nd leg) | Unión Española | - | Audax Italiano | 4:2 (3:1, 3:2) pso | ||
| 1st(1st leg): 08/10/2015 00:00 | 2nd (2nd leg): 11/10/2015 22:30 | Winner: Unión Española | ||||
| 1st(1st leg) | Copiapó | - | Colo-Colo | 2:3 (1:2) | ||
| 2nd (2nd leg) | Colo-Colo | - | Copiapó | 2:2 (2:1) | ||
| 1st(1st leg): 15/10/2015 00:00 | 2nd (2nd leg): 23/10/2015 00:00 | Winner: Colo-Colo | ||||
| 1st(1st leg) | Cobreloa | - | Universidad de Chile | 0:2 (0:0) | ||
| 2nd (2nd leg) | Universidad de Chile | - | Cobreloa | 3:0 (3:0) | ||
| 1st(1st leg): 15/10/2015 21:30 | 2nd (2nd leg): 22/10/2015 00:00 | Winner: Universidad de Chile | ||||
