03/07/2021 16:00 Asante Kotoko - King Faisal FC 1:1 (0:1)
16:00 WAFA - Inter Allies 1:0 (1:0)
20:00 Legon Cities - Bechem United 1:1 (1:0)
04/07/2021 16:00 Dreams FC - Berekum Chelsea 0:1 (0:1)
16:00 Great Olympics - Eleven Wonders 0:1 (0:0)
16:00 Liberty Professionals - Karela United 3:2 (2:1)
16:00 Medeama SC - Elmina Sharks 3:2 (2:2)
19:00 Ebusua Dwarfs - Hearts of Oak 1:1 (0:0)
05/07/2021 11:00 Aduana Stars - Ashanti Gold 1:0 (0:0)
# Team M. W D L goals Dif. Pt.
1 Hearts of Oak, Ghana Hearts of Oak 32 17 9 6 44:21 23 60
2 Asante Kotoko, Ghana Asante Kotoko 32 15 12 5 36:19 17 57
3 Medeama SC, Ghana Medeama SC 32 14 9 9 36:31 5 51
4 WAFA, Ghana WAFA 32 14 8 10 43:38 5 50
5 Great Olympics, Ghana Great Olympics 32 14 7 11 34:30 4 49
6 Aduana Stars, Ghana Aduana Stars 32 14 7 11 38:39 -1 49
7 Dreams FC, Ghana Dreams FC 32 13 9 10 44:33 11 48
8 Karela United, Ghana Karela United 32 12 10 10 41:37 4 46
9 Ashanti Gold, Ghana Ashanti Gold 32 10 11 11 43:36 7 41
10 Berekum Chelsea, Ghana Berekum Chelsea 32 11 7 14 36:44 -8 40
11 Legon Cities, Ghana Legon Cities 32 10 9 13 31:31 0 39
12 Eleven Wonders, Ghana Eleven Wonders 32 10 9 13 28:34 -6 39
13 Bechem United, Ghana Bechem United 32 10 9 13 35:44 -9 39
14 Ebusua Dwarfs, Ghana Ebusua Dwarfs 32 11 8 13 38:41 -3 38
15 Liberty Professionals, Ghana Liberty Professionals 32 10 8 14 32:44 -12 38
16 King Faisal FC, Ghana King Faisal FC 32 9 10 13 30:45 -15 37
17 Elmina Sharks, Ghana Elmina Sharks 32 8 11 13 31:45 -14 35
18 Inter Allies, Ghana Inter Allies 32 7 5 20 26:34 -8 26
  Champions League
  Relegation