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| 1st(1st leg) | UAG Tecos | - | Pumas UNAM | 2:0 (0:0) | ||
| 2nd (2nd leg) | Pumas UNAM | - | UAG Tecos | 3:0 (0:0) | ||
| 1st(1st leg): 14/05/2009 01:00 | 2nd (2nd leg): 16/05/2009 23:00 | Winner: Pumas UNAM | ||||
| 1st(1st leg) | Puebla FC | - | CF Monterrey | 3:1 (2:0) | ||
| 2nd (2nd leg) | CF Monterrey | - | Puebla FC | 2:2 (0:1) | ||
| 1st(1st leg): 14/05/2009 03:00 | 2nd (2nd leg): 17/05/2009 01:00 | Winner: Puebla FC | ||||
| 1st(1st leg) | Jaguares Chiapas | - | CF Pachuca | 1:3 (1:2) | ||
| 2nd (2nd leg) | CF Pachuca | - | Jaguares Chiapas | 2:0 (1:0) | ||
| 1st(1st leg): 14/05/2009 23:00 | 2nd (2nd leg): 18/05/2009 00:00 | Winner: CF Pachuca | ||||
| 1st(1st leg) | Indios Juárez | - | Deportivo Toluca | 1:0 (0:0) | ||
| 2nd (2nd leg) | Deportivo Toluca | - | Indios Juárez | 0:0 (0:0) | ||
| 1st(1st leg): 15/05/2009 01:00 | 2nd (2nd leg): 17/05/2009 18:00 | Winner: Indios Juárez | ||||
