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| 1st(1st leg) | UANL Tigres | - | Deportivo Guadalajara | 5:0 | ||
| 2nd (2nd leg) | Deportivo Guadalajara | - | UANL Tigres | 1:3 | ||
| 1st(1st leg): 09/05/2018 17:00 | 2nd (2nd leg): 12/05/2018 16:00 | Winner: UANL Tigres | ||||
| 1st(1st leg) | Pumas UNAM | - | CF América | 2:0 | ||
| 2nd (2nd leg) | CF América | - | Pumas UNAM | 2:0 | ||
| 1st(1st leg): 10/05/2018 16:00 | 2nd (2nd leg): 13/05/2018 17:00 | |||||
