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| 1st(1st leg) | Puebla FC | - | UANL Tigres | 2:1 | ||
| 2nd (2nd leg) | UANL Tigres | - | Puebla FC | 5:1 | ||
| 1st(1st leg): 02/05/2018 18:00 | 2nd (2nd leg): 05/05/2018 17:00 | Winner: UANL Tigres | ||||
| 1st(1st leg) | CF Pachuca | - | Deportivo Guadalajara | 2:3 | ||
| 2nd (2nd leg) | Deportivo Guadalajara | - | CF Pachuca | 4:2 | ||
| 1st(1st leg): 02/05/2018 18:00 | 2nd (2nd leg): 05/05/2018 18:00 | Winner: Deportivo Guadalajara | ||||
| 1st(1st leg) | Cruz Azul | - | CF América | 0:0 | ||
| 2nd (2nd leg) | CF América | - | Cruz Azul | 3:0 | ||
| 1st(1st leg): 02/05/2018 22:00 | 2nd (2nd leg): 05/05/2018 17:00 | Winner: CF América | ||||
| 1st(1st leg) | Santos Laguna | - | Pumas UNAM | 1:2 | ||
| 2nd (2nd leg) | Pumas UNAM | - | Santos Laguna | 4:1 | ||
| 1st(1st leg): 03/05/2018 17:00 | 2nd (2nd leg): 06/05/2018 16:00 | Winner: Pumas UNAM | ||||
