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| 1st(1st leg) | FK Drita | - | Sileks Kratovo | 1:2 (1:1) | ||
| 2nd (2nd leg) | Sileks Kratovo | - | FK Drita | 3:0 (1:0) | ||
| 1st(1st leg): 14/10/2012 13:00 | 2nd (2nd leg): 21/11/2012 13:00 | Winner: Sileks Kratovo | ||||
| 1st(1st leg) | FK Teteks | - | FK Renova | 0:0 (0:0) | ||
| 2nd (2nd leg) | FK Renova | - | FK Teteks | 0:1 (0:1) | ||
| 1st(1st leg): 14/10/2012 13:00 | 2nd (2nd leg): 21/11/2012 13:00 | Winner: FK Teteks | ||||
| 1st(1st leg) | KF Shkëndija 79 | - | Metalurg Skopje | 1:0 (1:0) | ||
| 2nd (2nd leg) | Metalurg Skopje | - | KF Shkëndija 79 | 1:5 (1:0) | ||
| 1st(1st leg): 14/10/2012 13:00 | 2nd (2nd leg): 21/11/2012 13:00 | Winner: KF Shkëndija 79 | ||||
| 1st(1st leg) | FK Pelister | - | Vardar Skopje | 0:1 (0:0) | ||
| 2nd (2nd leg) | Vardar Skopje | - | FK Pelister | 2:0 (0:0) | ||
| 1st(1st leg): 07/11/2012 12:00 | 2nd (2nd leg): 21/11/2012 17:00 | Winner: Vardar Skopje | ||||
