Third-tier Sheffield United confirmed their remarkable cup pedigree by eliminating Premier League Queens Park Rangers from the FA Cup with a 3-0 third-round victory at Loftus Road on Sunday.

Nigel Clough's League One side, who reached last season's semi-finals and face Tottenham Hotspur in the last four of this season's League Cup, won via a Marc McNulty goal and a second-half brace from Jamal Campbell-Ryce.

QPR, whose manager, Harry Redknapp, made seven changes to his starting XI, became the second top-flight team to be knocked out following Newcastle United's 1-0 loss at Leicester City on Saturday.

Premier League joint-leaders Manchester City were given a scare by second-tier Sheffield Wednesday before coming through 2-1 at the Etihad Stadium thanks a stoppage-time winner from James Milner.

Wednesday had lost 7-0 at City in the League Cup in September, but they took a 14th-minute lead through Atdhe Nuhiu, only for Milner, on his 29th birthday, to equalise in the 66th minute before snatching a last-gasp winner.

Southampton were taken to a replay by Championship side Ipswich Town after a 1-1 draw at St Mary's, while it took a stunning late strike by Christian Benteke for Aston Villa to overcome second-tier Blackpool 1-0.

Non-league Wrexham of the fifth-tier Football Conference came within 10 minutes of creating another piece of FA Cup history, only to lose 3-1 at top-flight Stoke City.

The Welsh side, who knocked out holders Arsenal in the third round in January 1992, went 1-0 up in the 73rd minute at the Britannia Stadium when Mark Carrington headed home a right-wing cross from Connor Jennings.

But with another famous upset beckoning, Marko Arnautovic stabbed home an equaliser in the 80th minute before Stephen Ireland claimed a late brace to send Mark Hughes's side through.

Alan Pardew made a winning start to life as manager of Crystal Palace, who won 4-0 at non-league Dover Athletic thanks to a first-half double by centre-back Scott Dann and goals from Dwight Gayle and Kevin Doyle.

Pardew was appointed Palace manager on Saturday after leaving Newcastle.

Meanwhile, Sunderland repeated their victory over Leeds United in the 1973 final with an identical 1-0 win against the Championship club at the Stadium of Light.

Sunderland, whose 1973 win was one of the biggest upsets in the competition's history, prevailed courtesy of a drilled 33rd-minute effort by Dutch left-back Patrick van Aanholt.

Holders Arsenal enter the competition later on Sunday when they host Hull City in a repeat of last season's final, which Arsene Wenger's side won 3-2.

Premier League co-leaders Chelsea host Championship side Watford, while Manchester United visit third-tier Yeovil Town.

Tottenham Hotspur travel to Burnley on Monday in a repeat of the 1962 final, which Spurs won, and Liverpool visit third-tier AFC Wimbledon for a tie that recalls the original Wimbledon's shock victory in the 1988 final.