Second-tier Sheffield Wednesday deepened Newcastle United's gloom by dumping them out of the League Cup with a 1-0 win on Wednesday, while Chelsea and Arsenal both reached round four.

Steve McClaren's Newcastle were looking to the League Cup for solace after a run of five games without victory in the Premier League, only to slump to a defeat that will increase scrutiny of the former England manager.

Lewis McGugan scored the game's only goal, beating Newcastle goalkeeper Tim Krul with a low, deflected shot from outside the box to send Wednesday into round four for the first time since they reached the last four in 2002.

Mathieu Flamini proved the unexpected match-winner with a first Arsenal brace as Arsene Wenger's side claimed a much-needed 2-1 win at arch-rivals Tottenham Hotspur in the north London derby.

Bidding to avoid three consecutive defeats for the first time since April 2010, Arsenal, who made 10 changes to Spurs' eight, took a 26th-minute lead when French holding midfielder Flamini followed in to score after Michel Vorm parried a long-range shot by Alex Oxlade-Chamberlain.

Spurs were rewarded for a spell of sustained pressure when Calum Chambers poked Nacer Chadli's cross into his own net in the 55th minute, only for Flamini to give Arsenal victory 12 minutes from time with a superb low volley from just outside the box.

Jose Mourinho's Chelsea continued their recent revival by winning 4-1 at third-tier Walsall to record a third consecutive victory.

Missing Diego Costa, who began a three-game ban for striking Arsenal's Laurent Koscielny at the weekend, but with captain John Terry back in the team, Chelsea went 2-0 up when Ramires headed home before teeing up Loic Remy to score.

James O'Connor squeezed a shot past Asmir Begovic to bring Walsall back into the game on the stroke of half-time, but second-half goals from full debutant Kenedy and Pedro Rodriguez sealed victory for the visitors.

Manchester United, second in the Premier League, are in action at home to second-tier Ipswich Town later, while Liverpool host League Two Carlisle United, the lowest-ranked team left in the competition.

Elsewhere, Jay Rodriguez, Sadio Mane and Shane Long all scored twice as Southampton swept into round four with a 6-0 rout of second-tier Milton Keynes Dons, who conquered Manchester United in last season's competition.

Dwight Gayle scored a hat-trick, including two penalties, as Crystal Palace beat Charlton Athletic 4-1, while Norwich City beat top-flight rivals West Bromwich Albion 3-0 courtesy of goals from Matt Jarvis, Kyle Lafferty and a Sebastien Pocognoli own goal.