1. Round | 13/09/2021 | Aris Saloniki | - | OFI Heraklion | 0:0 | ||||
2. Round | 19/09/2021 | OFI Heraklion | - | AEK Athen | 3:3 | ||||
3. Round | 22/09/2021 | OFI Heraklion | - | Asteras Tripolis | 0:0 | ||||
5. Round | 03/10/2021 | OFI Heraklion | - | PAOK Saloniki | 1:3 | ||||
21. Round | 02/02/2022 | OFI Heraklion | - | Panathinaikos | 3:2 | ||||
23. Round | 13/02/2022 | OFI Heraklion | - | Volos NFC | 2:1 | ||||
22. Round | 16/02/2022 | Atromitos | - | OFI Heraklion | 2:2 | ||||
25. Round | 27/02/2022 | Olympiakos Piraeus | - | OFI Heraklion | 2:0 |