1. Round | 16/07/2021 | River Plate II | - | Colón de Santa Fe II | 1:2 | ||||
2. Round | 23/07/2021 | Colón de Santa Fe II | - | Lanús II | 0:1 | ||||
3. Round | 27/07/2021 | Huracán II | - | Colón de Santa Fe II | 0:1 | ||||
4. Round | 30/07/2021 | Colón de Santa Fe II | - | Godoy Cruz II | 0:0 | ||||
5. Round | 06/08/2021 | Vélez Sarsfield II | - | Colón de Santa Fe II | 0:2 | ||||
6. Round | 13/08/2021 | Colón de Santa Fe II | - | Gimnasia de La Plata II | 2:1 | ||||
12. Round | 17/09/2021 | Colón de Santa Fe II | - | Central Córdoba SdE II | 0:1 | ||||
13. Round | 24/09/2021 | Boca Juniors II | - | Colón de Santa Fe II | 3:1 | ||||
14. Round | 01/10/2021 | Colón de Santa Fe II | - | Banfield II | 2:0 | ||||
15. Round | 11/10/2021 | San Lorenzo II | - | Colón de Santa Fe II | 1:1 | ||||
17. Round | 21/10/2021 | Argentinos Juniors II | - | Colón de Santa Fe II | 2:1 | ||||
21. Round | 17/11/2021 | Racing Club II | - | Colón de Santa Fe II | 1:1 | ||||
22. Round | 24/11/2021 | Colón de Santa Fe II | - | Rosario Central II | 1:1 | ||||
24. Round | 03/12/2021 | Colón de Santa Fe II | - | Atlético Tucumán II | 1:0 | ||||
25. Round | 09/12/2021 | Unión de Santa Fe II | - | Colón de Santa Fe II | 0:1 |