1. Round | 16/07/2021 | River Plate II | - | Colón de Santa Fe II | 1:2 | ||||
2. Round | 23/07/2021 | Colón de Santa Fe II | - | Lanús II | 0:1 | ||||
3. Round | 27/07/2021 | Huracán II | - | Colón de Santa Fe II | 0:1 | ||||
4. Round | 30/07/2021 | Colón de Santa Fe II | - | Godoy Cruz II | 0:0 | ||||
5. Round | 06/08/2021 | Vélez Sarsfield II | - | Colón de Santa Fe II | 0:2 | ||||
6. Round | 13/08/2021 | Colón de Santa Fe II | - | Gimnasia de La Plata II | 2:1 | ||||
8. Round | 24/08/2021 | Colón de Santa Fe II | - | Sarmiento de Junín II | 1:0 | ||||
9. Round | 27/08/2021 | Independiente II | - | Colón de Santa Fe II | 0:0 | ||||
10. Round | 03/09/2021 | Colón de Santa Fe II | - | Newell's Old Boys II | 1:1 | ||||
13. Round | 24/09/2021 | Boca Juniors II | - | Colón de Santa Fe II | 3:1 |