2. Round | 31/07/2021 | Club León | - | Club Tijuana | 2:1 | ||||
6. Round | 22/08/2021 | CF América | - | Club Tijuana | 2:0 | ||||
10. Round | 25/09/2021 | Club Tijuana | - | Mazatlán FC | 0:0 | ||||
12. Round | 04/10/2021 | Club Tijuana | - | Cruz Azul | 0:1 | ||||
13. Round | 15/10/2021 | Gallos Blancos | - | Club Tijuana | 1:1 | ||||
14. Round | 21/10/2021 | Club Tijuana | - | Deportivo Guadalajara | 0:0 | ||||
16. Round | 29/10/2021 | Atlas Guadalajara | - | Club Tijuana | 0:2 | ||||
17. Round | 07/11/2021 | Club Tijuana | - | CF Pachuca | 3:2 |