1. Round | 14/08/2021 | Heracles Almelo | - | PSV Eindhoven | 0:2 | ||||
2. Round | 21/08/2021 | Sparta Rotterdam | - | Heracles Almelo | 1:1 | ||||
3. Round | 29/08/2021 | Heracles Almelo | - | NEC Nijmegen | 0:1 | ||||
5. Round | 19/09/2021 | Heracles Almelo | - | AZ Alkmaar | 3:2 | ||||
6. Round | 23/09/2021 | SC Cambuur | - | Heracles Almelo | 2:1 | ||||
7. Round | 26/09/2021 | Heracles Almelo | - | RKC Waalwijk | 1:0 | ||||
8. Round | 02/10/2021 | Heracles Almelo | - | Willem II | 3:2 | ||||
9. Round | 16/10/2021 | Go Ahead Eagles | - | Heracles Almelo | 4:2 | ||||
10. Round | 23/10/2021 | PEC Zwolle | - | Heracles Almelo | 1:0 | ||||
11. Round | 30/10/2021 | Heracles Almelo | - | AFC Ajax | 0:0 | ||||
12. Round | 05/11/2021 | FC Twente | - | Heracles Almelo | 1:0 | ||||
13. Round | 20/11/2021 | Heracles Almelo | - | Fortuna Sittard | 3:1 | ||||
14. Round | 28/11/2021 | FC Utrecht | - | Heracles Almelo | 1:0 | ||||
4. Round | 01/12/2021 | Feyenoord | - | Heracles Almelo | 2:1 | ||||
15. Round | 04/12/2021 | Heracles Almelo | - | sc Heerenveen | 0:1 | ||||
19. Round | 15/01/2022 | NEC Nijmegen | - | Heracles Almelo | 0:0 | ||||
20. Round | 23/01/2022 | Heracles Almelo | - | Go Ahead Eagles | 1:1 |