1. Round | 04/04/2021 | Deportes Temuco | - | San Luis | 2:2 | ![]() |
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2. Round | 18/04/2021 | San Luis | - | Rangers | 0:1 | ||||
3. Round | 26/04/2021 | Puerto Montt | - | San Luis | 2:1 | ||||
9. Round | 07/06/2021 | San Luis | - | San Marcos | 0:1 | ||||
10. Round | 11/07/2021 | Santa Cruz | - | San Luis | 2:0 | ||||
11. Round | 15/07/2021 | Santiago Morning | - | San Luis | 0:0 | ||||
12. Round | 23/07/2021 | San Luis | - | Universidad de Concepción | 1:0 | ||||
13. Round | 01/08/2021 | Coquimbo Unido | - | San Luis | 0:1 |